Wetlands are susceptible to plant invasions. High connectivity of native vegetation surrounding wetlands may act as a landscape filter (barrier) to invasive plant dispersal and establishment. We examined the relationship between landscape vegetation connectivity (LVC) and wetland pest plant cover in wetlands of the Great Barrier Reef catchment area (GBRCA) using data from the GBRCA wetland condition monitoring program. LVC combines three ecologically important elements of connectivity: natural area (remnant vegetation and areas of regrowth) extent, condition and spatial separation. We expected wetlands with lower rather than higher LVC to harbour pest plants, as the former are surrounded by more human-disturbed corridors and fragmented natural habitat, potentially facilitating invasion. Results supported our prediction. Logistic regression showed that decrease in LVC increased the log odds of pest plant cover being non-negligible. Log odds were also higher for wetlands in non-conservation areas as opposed to conservation areas. However, there was no ‘tipping point’ along the LVC gradient between negligible and non-negligible pest plant cover, suggesting other factors, such as resource availability and dispersal mode, may play a role alongside habitat modification and loss of native vegetation connectivity in pest plant invasion of the wetlands.